THE Arizona Cardinals are one game out of the NFC West lead and look to keep their playoff hopes alive as they travel east to take on the Carolina Panthers on Sunday afternoon. The Cardinals (7-7) beat the Patriots last Sunday, 30-17, while the Panthers (3-11) lost at home to the Cowboys, 30-14. The teams last met in October 2022, a 26-16 road victory in Arizona. Arizona is 9-5 ATS, while Carolina is 6-8 ATS in 2024.
Kickoff from Bank of America Stadium is scheduled for 1 p.m. ET. Arizona is a 4.5-point favorite in the latest Cardinals vs. Panthers odds via the SportsLine consensus, while the over/under for total points is 47. Before making any Panthers vs. Cardinals picks, you need to see NFL predictions and betting tips from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, costs well over $7,000 for $100 players among the NFL’s highest-rated picks since its inception. The Model enters Week 16 of the 2024 NFL season at an incredible 27-11 bet hot streak on top rated NFL Pick This year. Longer term, he’s 207-139 on top-rated NFL picks dating back to the 2017 season and 61-32 on top-rated NFL picks since Week 7 of 2022.
The model has also ranked in the top 10 on NFLPickWatch four of the last six years on straight NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who follows sports betting and on betting apps experienced strong returns.
Now, the model has set its sights on Cardinals vs. Panthers and just locked in his NFL Week 16 picks and predictions. You can head over to SportsLine now to see the model’s choices. Here are several NFL Odds and betting lines for Cardinals vs. Panthers:
- Cardinals vs. Panthers spread: Cardinals -4.5
- Cardinals vs. Panthers plus/minus: 47 points
- Money line Cardinals vs. Panthers: Cardinals -225, Panthers +186
- Cardinals vs. Panthers picks: See the picks on SportsLine
- Cardinals vs. Panthers streaming: FuboTV (Try for free)
Why the Cardinals can cover
Can Trey McBride score a receiving touchdown this week? The Cardinals tight end has 89 receptions for 938 yards this season, but no receiving touchdowns. Although he scored on a short rushing touchdown in 2024, McBride currently holds the record for most catches in a season without a receiving touchdown. This will be a priority for the quarterback Kyler Murray to take care of his tight end, especially against a Panthers secondary that has given up 10 scores at that position this season (most in the NFL).
Run back James Conner should also have plenty of success against a Carolina defense giving up 173 rushing yards per game, 30 more than any other team in the league. Carolina has allowed an opposing running back to rush for at least 100 yards in three straight games and five of its last six. Conner has racked up 200 combined yards on 34 carries over his last two games and should once again be a key offensive weapon for the Cardinals offense this weekend. Find out which team to choose here.
Why the Panthers can cover
This will be the Chuba Hubbard show for Carolina again on Sunday. Although he was limited to just 10 carries for 32 yards against Dallas last week, the Panthers’ top running back has been excellent this year. With 1,043 rushing yards and nine total touchdowns, Hubbard made the most of his opportunity and turned it into a contract extension with Carolina.
Strategist Bryce Young has thrown at least one touchdown pass in seven straight games, which is a sign of progress for the former No. 1 overall pick. Last week he threw an 83-yard score to the rookie Jalen Cokerwho ended up with four receptions for 110 yards against the Cowboys. If Young can play turnover-free football (three interceptions in the last two weeks), the Panthers will have a good chance to pull off an upset at home in Week 16. Find out which team to choose here.
How to make Cardinals vs. Panthers picks
The model has simulated Arizona vs. Carolina 10,000 times and the results are in. It leans towards the point total and also indicates that one side of the spread is conceded well over 50% of the time. You can only see the Cardinals vs. Panthers model pick at SportsLine.
So who wins the Cardinals against the Panthers on Sunday, and which side of the spread is winning in well over 50% of simulations? Visit SportsLine now to see which side of the Arizona vs. Carolina spread you should be on Sunday, all from the model on a 207-139 outcome on its top-rated NFL picks.and find out.